Technical Ford 460 in F100

First post in a long time. I have a 62 Unibody F100, 460 ford out of 1974 Thunderbird and C6 Transmission. Has edelbrock carb, recently transmission was rebuilt. Now as soon as I drive and hit 60 mph the engine hesitates and will not accelerate more. I have tuned carb thinking mixture might be off, what else should I look for what else can it be?

Thank you in advance.

 

Have you verified that your throttle linkage is allowing the carburetor to fully open?

 

Check your fuel pressure (while driving). If you're sucking air (before the pump) or have a clogged filter it will do that.

 

Thank you both will check and come back to inform.