Nope - not even close. 300 intake forms the valley cover of the engine - 215 does not (among other differences). If you are looking for a good 4bbl manifold for your 300 - use a 64 aluminum factory manifold - fairly easy to find, and fits later cast iron heads - contrary to some info around.
No the 215 takes a steel intake gasket that covers the "valley" the 300" has the manifold made to cover the "valley" under the intake . 4 barrel manifolds are out there I found one for Carol's Fordoor & I do have a 215 engine .
I think you're pretty much out of luck - I don't know of any multi-carb manifolds that are available for the 300.
What year is the engine? '65-'67 300s have cast iron cylinder heads and the intakes interchange for those years, but the '64 300s with aluminum heads are a one year deal.
looks like im going with a vintage style y adapter from vintage speed, so i dont have to spend more money on a four barrel intake and still have the 2x2 setup.
If you're ultimately looking to wake up a 300, I'd go over here: http://www.buickperformancegroup.com/ ...and find Sean Etson. He has what is probably one of the fastest 300 powered Buick Specials in the country, and supposedly is the guru for making these engines come to life. he knows all the tricks. I think his car runs in the 11's or low 12's, and I believe it's a street car. He may even have the intake maniflold you need.
i dont need that much power. The motor is going in my model a so even in its stock form it would move the car along nicely, i just want a cool multi-carb set up.